Carlson G P
Toxicol Lett. 1980 Jan;5(1):19-25. doi: 10.1016/0378-4274(80)90143-5.
Commercial preparations of fire retardant brominated diphenyl ethers were tested along with bis (p-bromophenyl) ether and diphenyl ether for their ability to alter xenobiotic metabolism. The materials, 0.1 mmol/kg/day, were administered p.o. to male rats for 14 days. Pentabromodiphenyl and octabromodiphenyl ether preparations increased O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) detoxification, p-nitroanisole demethylation, NADPH-cytochrome c reductase, cytochrome P-450, liver weight, UDP-glucuronyltransferase and benzo[a]pyrene hydroxylase. Diphenyl ether increased only EPN detoxification and decabromodiphenyl ether only liver weight. Bis(p-bromophenyl) ether increased liver weight, cytochrome c reductase and cytochrome P-450. The data indicate that these materials are inducers of xenobiotic metabolism with activity dependent upon degree of bromination.
对阻燃溴化二苯醚的商业制剂以及双（对溴苯基）醚和二苯醚改变外源性物质代谢的能力进行了测试。将这些物质以0.1 mmol/kg/天的剂量经口给予雄性大鼠，持续14天。五溴二苯醚和八溴二苯醚制剂增加了对O-乙基-O-对硝基苯基苯基硫代磷酸酯（EPN）的解毒作用、对硝基苯甲醚脱甲基作用、NADPH-细胞色素c还原酶、细胞色素P-450、肝脏重量、UDP-葡萄糖醛酸转移酶和苯并[a]芘羟化酶。二苯醚仅增加了EPN解毒作用，而十溴二苯醚仅增加了肝脏重量。双（对溴苯基）醚增加了肝脏重量、细胞色素c还原酶和细胞色素P-450。数据表明这些物质是外源性物质代谢的诱导剂，其活性取决于溴化程度。
