Carlson G P, Smith E N, Johnson K M
Drug Chem Toxicol. 1980;3(3):293-303. doi: 10.3109/01480548009002224.
Chlorinated diphenyl ether isomers were administered to rats at doses of 10 mumols/kg/day po for 3 days. Decachlorodiphenyl ether caused increases in EPN detoxification, NADPH cytochrome c reductase and cytochrome P-450 but did not alter aryl hydrocarbon hydroxylase (AHH). It caused a shift in P450 absorption to 448 nm. 2,4,5,2',4'-Pentachlorodiphenyl ether increased EPN detoxification and cytochrome P-450. 2,4,5,3',4'-Pentachlorodiphenyl ether increased AHH and cytochrome P-450 and caused a shift in the absorption maximum to 448 nm. 3,4,2',4'-Tetrachlorodiphenyl ether induced AHH. 2,4'-Dichlorodiphenyl ether, 4,4'-dichlorodiphenyl ether, 2,4,2'-trichlorodiphenyl ether, 2,4,4'-trichlorodiphenyl ether, 3,4,2'-trichlorodiphenyl ether and 3,4,2',4'-tetrachlorodiphenyl ether did not alter any of these parameters. The position and degree of chlorination are important in determining the extent of induction and pathways induced.
以10微摩尔/千克/天的剂量经口给大鼠施用氯化二苯醚异构体，持续3天。十氯二苯醚导致EPN解毒、NADPH细胞色素c还原酶和细胞色素P - 450增加，但未改变芳烃羟化酶（AHH）。它使P450的吸收峰移至448纳米。2,4,5,2',4'-五氯二苯醚增加了EPN解毒和细胞色素P - 450。2,4,5,3',4'-五氯二苯醚增加了AHH和细胞色素P - 450，并使最大吸收峰移至448纳米。3,4,2',4'-四氯二苯醚诱导了AHH。2,4'-二氯二苯醚、4,4'-二氯二苯醚、2,4,2'-三氯二苯醚、2,4,4'-三氯二苯醚、3,4,2'-三氯二苯醚和3,4,2',4'-四氯二苯醚未改变任何这些参数。氯取代的位置和程度对于确定诱导的程度和诱导途径很重要。
