Schumann G B, Lerner S I, Weiss M A, Gawronski L, Lohiya G K
Am J Clin Pathol. 1980 Aug;74(2):192-6. doi: 10.1093/ajcp/74.2.192.
Histochemical and microscopic studies have shown that a characteristic renal response to lead exposure is the formation of discrete, dense, staining intranuclear inclusion bodies in renal tubular epithelial cells. Cytologic examination of urinary sediment showed that four of 19 (21%) lead workers had exfoliated inclusion-bearing cells of proximal renal tubular origin. These lead-induced inclusion-bearing cells appeared distinctly different from viral-induced inclusions, degenerative or nonspecific intranuclear inclusions seen with tubular necrosis, or macronucleoli seen in reparative renal tubular epithelium. While their presence indicates cytologic evidence of tubular injury, the clinical significance of these cells and their application to medical monitoring is not clearly understood.
组织化学和显微镜研究表明，肾脏对铅暴露的特征性反应是在肾小管上皮细胞中形成离散、致密、染色的核内包涵体。尿沉渣的细胞学检查显示，19名铅作业工人中有4名（21%）有来自近端肾小管的含包涵体细胞脱落。这些铅诱导的含包涵体细胞与病毒诱导的包涵体、肾小管坏死时出现的退行性或非特异性核内包涵体或修复性肾小管上皮中出现的大核仁明显不同。虽然它们的存在表明有肾小管损伤的细胞学证据，但这些细胞的临床意义及其在医学监测中的应用尚不清楚。
