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自发性高血压大鼠对可乐定的生长激素反应增强。

Enhanced growth hormone response to clonidine in the spontaneously hypertensive rat.

作者信息

Eriksson E, Edén S, Modigh K

出版信息

Clin Exp Hypertens (1978). 1980 Feb;2(2):341-6. doi: 10.3109/10641968009046428.

DOI:10.3109/10641968009046428
PMID:6251998
Abstract

Plasma concentrations of growth hormone (GH) were measured after administration of clonidine (0.5 mg/kg) to spontaneously hypertensive (SH) rats and normotensive Wistar Kyoto controls. All rats were pretreated with reserpine (10 mg/kg). The GH response to clonidine was significantly higher in SH rats than in controls, indicating that in SH rats the responsiveness of post-synaptic alpha-adrenergic structures in the hypothalamus may be increased.

摘要

给自发性高血压(SH)大鼠和正常血压的Wistar Kyoto对照大鼠注射可乐定(0.5毫克/千克)后,测量其血浆生长激素(GH)浓度。所有大鼠均预先用利血平(10毫克/千克)进行预处理。SH大鼠对可乐定的GH反应明显高于对照组,这表明在SH大鼠中,下丘脑突触后α-肾上腺素能结构的反应性可能增强。

相似文献

1
Enhanced growth hormone response to clonidine in the spontaneously hypertensive rat.自发性高血压大鼠对可乐定的生长激素反应增强。
Clin Exp Hypertens (1978). 1980 Feb;2(2):341-6. doi: 10.3109/10641968009046428.
2
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Up- and down- regulation of central postsynaptic alpha 2 receptors reflected in the growth hormone response to clonidine in reserpine-pretreated rats.利血平预处理大鼠中,生长激素对可乐定的反应所反映的中枢突触后α2受体的上调和下调。
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alpha2-Adrenergic stimulation enhances growth hormone secretion in the dog: a presynaptic mechanism?α2-肾上腺素能刺激增强犬生长激素分泌:一种突触前机制?
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引用本文的文献

1
Up- and down- regulation of central postsynaptic alpha 2 receptors reflected in the growth hormone response to clonidine in reserpine-pretreated rats.利血平预处理大鼠中,生长激素对可乐定的反应所反映的中枢突触后α2受体的上调和下调。
Psychopharmacology (Berl). 1982;77(4):327-31. doi: 10.1007/BF00432764.
2
Effects of sex steroids on growth hormone responses to clonidine and GHRH in reserpine pretreated rats.性类固醇对利血平预处理大鼠生长激素对可乐定和生长激素释放激素反应的影响。
J Neural Transm. 1988;71(2):99-113. doi: 10.1007/BF01245252.
3
Locus coeruleus neurons show reduced alpha 2-receptor responsiveness and decreased basal activity in spontaneously hypertensive rats.
在自发性高血压大鼠中,蓝斑神经元表现出α2受体反应性降低和基础活动减少。
J Neural Transm. 1987;69(1-2):71-83. doi: 10.1007/BF01244098.