Brogden R N, Carmine A, Heel R C, Morley P A, Speight T M, Avery G S
Drugs. 1981 Dec;22(6):423-60. doi: 10.2165/00003495-198122060-00002.
Cefoperazone is a new 'third generation' semisynthetic injectable cephalosporin. It has a broad spectrum of antibacterial activity which includes Pseudomonas aeruginosa (unlike older cephalosporins), along with the Enterobacteriaceae and other Gram-negative bacteria, Gram-positive bacteria and anaerobic bacteria. Unlike other cephalosporins, cefoperazone is excreted to a considerable extent by extrarenal mechanisms. Given by intravenous or intramuscular injection, cefoperazone is effective against a wide variety of infections caused by Gram-negative or Gram-positive aerobes, including infections of the biliary tract, and in many anaerobic infections. It is generally well tolerated, diarrhoea and skin rashes being the most frequently reported side effects.
头孢哌酮是一种新型的“第三代”半合成注射用头孢菌素。它具有广谱抗菌活性，包括铜绿假单胞菌（与 older cephalosporins 不同），以及肠杆菌科细菌和其他革兰氏阴性菌、革兰氏阳性菌和厌氧菌。与其他头孢菌素不同，头孢哌酮在很大程度上通过肾外机制排泄。通过静脉或肌肉注射给药，头孢哌酮对由革兰氏阴性或革兰氏阳性需氧菌引起的多种感染有效，包括胆道感染以及许多厌氧菌感染。它通常耐受性良好，腹泻和皮疹是最常报告的副作用。
