鼠巨细胞病毒在鼠类和异种脑细胞培养物中的生长。简要报告。
Growth of murine cytomegalovirus in murine and heterologous brain cell cultures. Brief report.
作者信息
Barabas G, Wroblewska Z, Gilden D H
出版信息
Arch Virol. 1980;65(2):193-200. doi: 10.1007/BF01317331.
PMID:6252869
Abstract
Murine cytomegalovirus (MCMV) produced a cytopathic effect in mouse brain, guinea pig embryonic brain, human brain and fibroblast cells. Virus-specific antigen was detected by immunofluorescence in these cells after primary infection with MCMV. MCMV also replicated in ouse embryo brain and guinea pig brain cells. Although definite evidence of MCMV replication could not be demonstrated in human cells, MCMV infectivity was maintained for 12 days in human cell cultures.
摘要
鼠巨细胞病毒（MCMV）可在小鼠脑、豚鼠胚胎脑、人脑及成纤维细胞中产生细胞病变效应。初次感染MCMV后，通过免疫荧光法在这些细胞中检测到病毒特异性抗原。MCMV也在小鼠胚胎脑和豚鼠脑细胞中复制。虽然无法在人细胞中证实MCMV复制的确切证据，但MCMV在人细胞培养物中可保持感染性达12天。
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