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支气管癌异种移植的治疗反应：患者与异种移植的直接比较

The therapeutic response of bronchial carcinoma xenografts: a direct patient-xenograft comparison.

作者信息

Shorthouse A J, Peckham M J, Smyth J F, Steel G G

出版信息

Br J Cancer Suppl. 1980 Apr;4:142-5.

PMID:6252930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149243/
Abstract

The chemotherapeutic response of a series of patients with bronchial carcinoma has been compared with the response of their xenografts established in immune-suppressed CBA/lac mice. Xenograft response was assessed by the in situ endpoint of growth delay in subcutaneous tumours. Histology and chromosome analysis indicated that human characteristics were retained in the xenografts. 49 xenograft lines were attempted: 15/18 oat cell, 11/17 squamous, 6/8 large cell anaplastic and 6/6 adenocarcinomas were successfully established. 14 Lines (28%) were available (August 1979) for direct comparison of xenograft and donor patient response to the same chemotherapeutic agents. A positive correlation was found and provides support for the chemotherapeutic validity of xenografts.

摘要

对一系列支气管癌患者的化疗反应与其在免疫抑制的CBA/lac小鼠体内建立的异种移植瘤的反应进行了比较。通过皮下肿瘤生长延迟的原位终点来评估异种移植瘤的反应。组织学和染色体分析表明异种移植瘤保留了人类特征。共尝试建立49个异种移植瘤系：燕麦细胞癌15/18成功建立，鳞状细胞癌11/17成功建立，大细胞间变性癌6/8成功建立，腺癌6/6成功建立。1979年8月有14个系（28%）可用于直接比较异种移植瘤和供体患者对相同化疗药物的反应。发现了正相关关系，这为异种移植瘤的化疗有效性提供了支持。

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本文引用的文献

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Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.抗癌药物在小鼠、大鼠、仓鼠、狗、猴和人类中毒性的定量比较。
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Improved immune-suppression techniques for the exongrafting of human tumours.用于人体肿瘤外植的改进免疫抑制技术。
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