人类肿瘤异种移植：批判性评估。
Human tumour xenografts: a critical appraisal.
作者信息
Steel G G, Peckham M J
出版信息
Br J Cancer Suppl. 1980 Apr;4:133-41.
Abstract
Human tumours grown in immune-deficient mice are available for studies in experimental pathology and therapeutics. In addition to growth-delay experiments clonogenic assays can sometimes be performed. Xenografts often retain some characteristics of the source tumour but the amount of precise information on the maintenance of therapeutic sensitivity is small. Principal drawbacks include the difficulty of matching with human doses the dose of drugs given to the host mouse, and the probable existence of a substantial host reaction against the grafts. Principal benefits may be to studies that involve the intercomparison of human tumours in regard to therapeutic response.
摘要
在免疫缺陷小鼠体内生长的人类肿瘤可用于实验病理学和治疗学研究。除生长延迟实验外，有时还可进行克隆形成测定。异种移植瘤通常保留源肿瘤的一些特征，但关于维持治疗敏感性的精确信息较少。主要缺点包括难以将给予宿主小鼠的药物剂量与人类剂量相匹配，以及可能存在针对移植瘤的大量宿主反应。主要益处可能在于涉及人类肿瘤治疗反应相互比较的研究。
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