Moneret DA Vautrin D A, Duc M, Sigiel M
Ann Anesthesiol Fr. 1976;17(2):165-76.
From this study an important notion emerges concerning the risk factors in accidents due to general anaesthetics and myorelaxants. Among these factors, three are clinical parameters which can be assessed by any anaesthetist: the presence of atopy, of a previous drug allergy, of previous, repeated general anaesthesia, close together in timel Two factors were the subject of an experimental study, routinely investigating an abnormal histamine reactivity of the skin, and a latent spasmophilia. No definite conclusion can be made from the results, bearing in mind certain criticisms of technical order and the small number of subjects investigated. However, these works merit being pursued. Thus, if all subjects are not equal when faced with the risks inherent to anaesthesia, a thorough study of individual risk factors will enable a preventive approach, utilising a premedication prescribed with mature consideration.
从这项研究中，出现了一个关于全身麻醉药和肌松药导致事故的风险因素的重要概念。在这些因素中，有三个是任何麻醉医生都可以评估的临床参数：特应性、既往药物过敏、既往近期反复全身麻醉。有两个因素是一项实验研究的主题，该研究常规调查皮肤异常组胺反应性和潜在的痉挛倾向。考虑到技术层面的某些批评以及所调查对象数量较少，无法从结果中得出明确结论。然而，这些工作值得继续开展。因此，如果在面对麻醉固有风险时所有患者并不相同，那么对个体风险因素进行全面研究将有助于采取预防措施，即采用经过深思熟虑后开具的术前用药。
