Ostör A G, Fortune D W
Histopathology. 1980 Jul;4(4):369-82. doi: 10.1111/j.1365-2559.1980.tb02932.x.
The clinico-pathological features of 11 examples of a rare group of uterine neoplasms composed of both epithelial and stromal components are reported. The patients complained of abnormal vaginal bleeding or discharge. Two of the tumours arose in the cervix, seven in the endometrium and two from both, forming large polypoid masses projecting from the cervix and/or filling the uterine cavity. Microscopically, the epithelial elements ranged from benign to adenocarcinoma. A similar range of stromal elements was also seen, varying from entirely bland to low grade to high grade sarcoma. The variable histology of the tumours is reflected in their biologic behaviour. Of the three tumours with the highest histological grade of malignancy, one recurred and killed the patient. One tumour, in which both components were regarded histologically as benign, recurred twice before hysterectomy. Our findings lend support to the concept that these tumours are variants of mixed Müllerian tumour. We advocate the acceptance of the latter term so that all grades of this tumour can be accommodated under one designation.
本文报告了11例由上皮和间质成分组成的罕见子宫肿瘤的临床病理特征。患者主诉阴道异常出血或分泌物。其中2例肿瘤发生于宫颈，7例发生于子宫内膜，2例同时累及宫颈和子宫内膜，形成从宫颈突出的大息肉样肿物和/或充满子宫腔。显微镜下，上皮成分从良性到腺癌不等。间质成分也呈现类似范围的变化，从完全无异型性到低级别再到高级别肉瘤。肿瘤组织学的多样性反映在其生物学行为上。在组织学恶性程度最高的3例肿瘤中，1例复发并导致患者死亡。1例肿瘤的两个成分在组织学上均被视为良性，但在子宫切除术前复发了两次。我们的研究结果支持这些肿瘤是混合性苗勒管肿瘤变异型的概念。我们主张采用后一术语，以便将该肿瘤的所有级别都纳入一个命名之下。
