血小板衍生生长因子对3T3细胞上表皮生长因子受体的调节作用
Modulation of epidermal growth factor receptors on 3T3 cells by platelet-derived growth factor.
作者信息
Wrann M, Fox C F, Ross R
出版信息
Science. 1980 Dec 19;210(4476):1363-5. doi: 10.1126/science.6254158.
PMID:6254158
Abstract
Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors. These data suggest a common cellular internalization mechanism for the receptors for both hormones.
摘要
血小板衍生生长因子并不与表皮生长因子（EGF）竞争结合小鼠3T3细胞表面的EGF受体，但它以两种方式调节EGF受体：（i）它诱导EGF受体的短暂下调，以及（ii）它抑制EGF诱导的EGF受体下调。这些数据提示这两种激素的受体存在共同的细胞内化机制。
Zotero 插件