Soike K F, Gary G W, Gibson S
Am J Vet Res. 1980 Jul;41(7):1098-1103.
Enzyme-linked immunosorbent assay examination of sera from three nonhuman primate species demonstrated the presence of antibody reacting with simian rotavirus SA-11 and calf rotavirus C486. The occurrence of this antibody in sera from adult, wild-caught animals suggests natural rotovirus infection. The occurrence of antibody was highest in the chimpanzee and declined, respectively, in the rhesus macaque and in the squirrel monkey. Inoculation of three infant rhesus macaques, a nursery-reared chimpanzee, and a cesarian-derived nursery-reared baboon with SA-11 virus resulted in enteric infection, with virus excretion beginning 48 to 72 hours after oral administration of the virus. Clinical disease, as manifested by diarrhea, was observed only in the chimpanzee. Inoculation of ten squirrel monkeys, from 30 to 191 days old, induced infection only in the monkey inoculated at 30 days of age. This monkey became ill within 48 hours after viral administration and was euthanatized. Necropsy demonstrated a generalized infection, with virus recovered from lung, liver, kidney, spleen, and intestine. The remaining nine inoculated squirrel monkeys failed to develop enteric infection and did not respond with antibody to SA-11 virus.
对三种非人灵长类动物的血清进行酶联免疫吸附测定检查，结果显示存在与猿猴轮状病毒SA - 11和牛轮状病毒C486发生反应的抗体。在成年野生捕获动物的血清中出现这种抗体，表明存在自然轮状病毒感染。抗体的出现率在黑猩猩中最高，在恒河猴和松鼠猴中则分别下降。用SA - 11病毒接种三只幼年恒河猴、一只饲养在保育室的黑猩猩和一只剖腹产出生并饲养在保育室的狒狒，导致肠道感染，在口服病毒后48至72小时开始排出病毒。仅在黑猩猩中观察到以腹泻为表现的临床疾病。对10只30至191日龄的松鼠猴进行接种，仅在30日龄接种的那只猴子中引发了感染。这只猴子在接种病毒后48小时内发病并被实施安乐死。尸检显示全身性感染，在肺、肝、肾、脾和肠道中均检测到病毒。其余9只接种的松鼠猴未发生肠道感染，且对SA - 11病毒未产生抗体反应。
