肠道病毒感染的非人灵长类动物模型。
Non-Human Primate Models of Enteric Viral Infections.
机构信息
Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA.
PreCliniTria, LLC, Mandeville, LA 70471, USA.
出版信息
Viruses. 2018 Oct 5;10(10):544. doi: 10.3390/v10100544.
There is an important role non-human primates (NHP) play in biomedical research. Phylogenetic proximity of any of the NHP species to assures that much better translatability of research outcomes from model studies involving human diseases can be achieved than from those generated with other pre-clinical systems. Our group and others used during past two decades NHPs in research directed towards viral and autoimmune disorders of the gastrointestinal tract. This review summarizes progress made in the area of enteric viral infections including its applicability to human disease.
非人类灵长类动物（NHP）在生物医学研究中具有重要作用。任何 NHP 物种与人类的进化亲缘关系都非常接近，这确保了从涉及人类疾病的模型研究中获得的研究结果具有更好的转化性，而不是从其他临床前系统中获得的结果。在过去的二十年中，我们小组和其他小组使用 NHP 进行了针对胃肠道病毒和自身免疫性疾病的研究。这篇综述总结了在肠病毒感染领域取得的进展，包括其在人类疾病中的应用。
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