Cheng P T, Pritzker K P, Adams M E, Nyburg S C, Omar S A
J Rheumatol. 1980 Sep-Oct;7(5):609-16.
Pseudogout is characterized by the deposition of calcium pyrophosphate dihydrate, triclinic [CPPD(T)] and calcium pyrophosphate dihydrate, monoclinic [CPPD(M)] crystals in articular connective tissues. We studied aqueous solutions over a range of calcium chloride/sodium pyrophosphate concentrations to determine the ionic conditions under which these particular salts form. At 37 degrees C, CPPD(T) forms when [PPi]t greater than or equal to 10(-4), while formation of CPPD(M) occurs at 10(-3) M < [PPi]t less than or equal to 10(-2) M. When [Na+]t > 120 mM, calcium disodium pyrophosphates precipitate. With 1 mM Mg++, CPPD(M) forms at [PPi]t > 10(-3) M, mixed with a calcium magnesium pyrophosphate at [PPi]t greater than or equal to 10(-2) M. We conclude that CPPD(T) and CPPD(M) crystals form in a restricted ratio and range of [Ca++]t and [PPi]t and that other ions, particularly Mg++ and Na+, affect the nature of the crystal products formed.
假性痛风的特征是二水焦磷酸钙三斜晶型[CPPD(T)]和二水焦磷酸钙单斜晶型[CPPD(M)]晶体在关节结缔组织中沉积。我们研究了一系列氯化钙/焦磷酸钠浓度下的水溶液，以确定形成这些特定盐类的离子条件。在37摄氏度时，当[PPi]t大于或等于10^(-4)时形成CPPD(T)，而当10^(-3) M < [PPi]t小于或等于10^(-2) M时形成CPPD(M)。当[Na+]t > 120 mM时，焦磷酸二钠钙沉淀。当存在1 mM Mg++时，在[PPi]t > 10^(-3) M时形成CPPD(M)，在[PPi]t大于或等于10^(-2) M时与焦磷酸钙镁混合。我们得出结论，CPPD(T)和CPPD(M)晶体在[Ca++]t和[PPi]t的特定比例和范围内形成，并且其他离子，特别是Mg++和Na+，会影响所形成晶体产物的性质。
