阿维菌素B1a，一种能使蛔虫的中间神经元和抑制性运动神经元麻痹的驱虫药。
Avermectin B1a, a paralyzing anthelmintic that affects interneurons and inhibitory motoneurons in Ascaris.
作者信息
Kass I S, Wang C C, Walrond J P, Stretton A O
出版信息
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6211-5. doi: 10.1073/pnas.77.10.6211.
Abstract
Avermectin B1a (AVM) is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis. Using selective stimulation techniques, we have shown that AVM blocks transmission between interneuron(s) and excitatory motorneurons in the ventral nerve cord of Ascaris. It also inhibits transmissin between inhibitory motoneurons and muscle but has little effect on excitatory neuromuscular transmission. Picrotoxin can reverse the AVM-induced block of interneuron-excitatory motoneuron transmission but has no effect on the inhibitory motoneuronal synapse in either the presence or absence of AVM. Our results provide an explanation of how AVM may cause paralysis of nematodes.
摘要
阿维菌素B1a（AVM）是一种抗寄生虫剂，可使线虫麻痹，而不会引起过度收缩或弛缓性麻痹。运用选择性刺激技术，我们已证明AVM可阻断蛔虫腹神经索中中间神经元与兴奋性运动神经元之间的信号传递。它还会抑制抑制性运动神经元与肌肉之间的信号传递，但对兴奋性神经肌肉传递影响甚微。印防己毒素可逆转AVM诱导的中间神经元-兴奋性运动神经元信号传递阻断，但无论有无AVM，对抑制性运动神经元突触均无影响。我们的研究结果解释了AVM如何导致线虫麻痹。
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本文引用的文献
1
The specificity of high affinity binding of avermectin B1a to mammalian brain.阿维菌素B1a与哺乳动物大脑高亲和力结合的特异性。
Neuropharmacology. 1980 Mar;19(3):311-7. doi: 10.1016/0028-3908(80)90155-0.
2
Studies on the mechanism of action of avermectin B1a: stimulation of release of gamma-aminobutyric acid from brain synaptosomes.阿维菌素B1a作用机制的研究：刺激脑突触体释放γ-氨基丁酸
J Neurochem. 1980 Feb;34(2):351-8. doi: 10.1111/j.1471-4159.1980.tb06604.x.
3
Inhibitory action of gamma-aminobutyric acid (GABA) on Ascaris muscle.
Experientia. 1964 Mar 15;20(3):141-3. doi: 10.1007/BF02150701.
4
The biochemistry of helminths.蠕虫的生物化学
Z Parasitenkd. 1974;45(2):109-24. doi: 10.1007/BF00348531.
5
Some pharmacodynamic effects of the nematocides: methyridine, tetramisole and pyrantel.杀线虫剂：甲噻嘧啶、四咪唑和噻嘧啶的一些药效学作用。
J Pharm Pharmacol. 1970 Jan;22(1):26-36. doi: 10.1111/j.2042-7158.1970.tb08380.x.
6
The genetics of Caenorhabditis elegans.秀丽隐杆线虫的遗传学
Genetics. 1974 May;77(1):71-94. doi: 10.1093/genetics/77.1.71.
7
Insecticidal activity of the anti-parasitic avermectins.抗寄生虫阿维菌素的杀虫活性。
Vet Rec. 1979 Aug 25;105(8):168. doi: 10.1136/vr.105.8.168-a.
8
Avermectins, new family of potent anthelmintic agents: efficacy of the B1a component.阿维菌素，一类新型高效驱虫药：B1a组分的疗效
Antimicrob Agents Chemother. 1979 Mar;15(3):372-8. doi: 10.1128/AAC.15.3.372.
9
Avermectins, new family of potent anthelmintic agents: isolation and chromatographic properties.阿维菌素，一类新型高效驱虫剂：分离与色谱特性
Antimicrob Agents Chemother. 1979 Mar;15(3):368-71. doi: 10.1128/AAC.15.3.368.
10
Avermectins, new family of potent anthelmintic agents: producing organism and fermentation.阿维菌素，一类新型高效驱虫药：产生菌与发酵
Antimicrob Agents Chemother. 1979 Mar;15(3):361-7. doi: 10.1128/AAC.15.3.361.
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