阿维菌素，一类新型高效驱虫剂：分离与色谱特性
Avermectins, new family of potent anthelmintic agents: isolation and chromatographic properties.
作者信息
Miller T W, Chaiet L, Cole D J, Cole L J, Flor J E, Goegelman R T, Gullo V P, Joshua H, Kempf A J, Krellwitz W R, Monaghan R L, Ormond R E, Wilson K E, Albers-Schönberg G, Putter I
出版信息
Antimicrob Agents Chemother. 1979 Mar;15(3):368-71. doi: 10.1128/AAC.15.3.368.
Abstract
The avermectins, a family of new anthelmintic agents, were isolated from the mycelia of Streptomyces avermitilis. Four closely related major components and four homologous minor components were separated from the complex. Solvent extraction, solvent partition, and adsorption methods were used to isolate and purify the complex; novel partition chromatography systems using Sephadex LH-20 were used to separate the components. A reverse-phase high-pressure liquid chromatography assay for the quantitative determination of all components was used extensively to monitor the purification methods.
摘要
阿维菌素是一类新型驱虫药，从阿维链霉菌的菌丝体中分离得到。从该复合物中分离出了四种密切相关的主要成分和四种同源次要成分。采用溶剂萃取、溶剂分配和吸附方法对该复合物进行分离和纯化；使用Sephadex LH - 20的新型分配色谱系统分离各成分。一种用于定量测定所有成分的反相高压液相色谱分析法被广泛用于监测纯化方法。
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本文引用的文献
1
Avermectins, new family of potent anthelmintic agents: efficacy of the B1a component.阿维菌素，一类新型高效驱虫药：B1a组分的疗效
Antimicrob Agents Chemother. 1979 Mar;15(3):372-8. doi: 10.1128/AAC.15.3.372.
2
Avermectins, new family of potent anthelmintic agents: producing organism and fermentation.阿维菌素，一类新型高效驱虫药：产生菌与发酵
Antimicrob Agents Chemother. 1979 Mar;15(3):361-7. doi: 10.1128/AAC.15.3.361.
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