Federico G, Pizzigallo E, Nervo P, Ranno O, Ortona L
Boll Ist Sieroter Milan. 1980 Jan 31;58(6):445-52.
In the present work the Authors report the results of the research of HAAb in 383 subjects living in Rome with negative history for hepatitis (divided for age, sex and occupation) and in 64 acute non B hepatitis (HBsAg-). In the latter, the titer of HAAb was determined at the beginning and later during the course of the disease. A fractionation of 13 sera of these patients was done and the type of specific immunoglobulin was determined. Among the subject with negative history for hepatitis, 68.9% was positive during first 6 months of age 6.2% from 6 months to 5 y.o., 27.6% from 6 to 12 y.o., 45.4% from 12 to 17 y.o., 76.8% from 18 to 25 y.o., 82.2% from 26 to 45 y.o., 90.2% from 46 to 65 y.o.. There was no statistically significant difference either between males and females, or among various occupations. Among the 64 patients with non B hepatitis, 25 (39%) were hepatitis A (because they showed either a seroconversion for HAAb or a positive HAAb-IgM); 12 (18.7%) were non A-non B hepatitis because HAAb negative or HAAb positive but negative for HAAb-IgM; while 27 (42.2%) were impossible to classify because they showed a positivity for HAAb but not a seroconversion during the disease. The limit of the determination of HAAb and the utility of the research of IgM antibody for the diagnosis of hepatitis A are discussed.
在本研究中，作者报告了对383名居住在罗马且无肝炎病史的受试者（按年龄、性别和职业划分）以及64例急性非乙型肝炎（HBsAg阴性）患者进行甲型肝炎抗体（HAAb）研究的结果。对于后者，在疾病开始时及病程后期测定了HAAb滴度。对其中13例患者的血清进行了分离，并确定了特异性免疫球蛋白的类型。在无肝炎病史的受试者中，6个月以下婴儿HAAb阳性率为68.9%，6个月至5岁为6.2%，6至12岁为27.6%，12至17岁为45.4%，18至25岁为76.8%，26至45岁为82.2%，46至65岁为90.2%。男性与女性之间以及不同职业之间均无统计学显著差异。在64例非乙型肝炎患者中，25例（39%）为甲型肝炎（因为他们显示出HAAb血清学转换或HAAb-IgM阳性）；12例（18.7%）为非甲非乙型肝炎，因为HAAb阴性或HAAb阳性但HAAb-IgM阴性；而27例（42.2%）无法分类，因为他们显示HAAb阳性但在疾病期间未出现血清学转换。文中讨论了HAAb测定的局限性以及IgM抗体研究对甲型肝炎诊断的实用性。
