33例急性乙型肝炎表面抗原阴性、甲型肝炎病毒抗体阳性的病毒性肝炎中的乙型肝炎和甲型肝炎标志物。免疫复合物的重要性
[Hepatitis B and hepatitis A markers in 33 cases of acute hepatitis B surface antigen-negative, hepatitis A virus antibody-positive viral hepatitis. Importance of immune complexes].
作者信息
Raise E, Bonazzi L, Cucci A M, Imbastaro T, Nucci S, Boni P, Miniero R, Lenzi G
出版信息
Minerva Med. 1982 Apr 28;73(18):1169-72.
The authors have looked for the markers of HBV by R.I.A. method (HBsAg, anti HBsAg, HBeAg, anti HBeAg, anti HBcAg), of HAV (by measurement on two samples of HAVab or by measurement of HAVab IgM), the immune-complexes (I.C.C.) by C1q solid-phase binding assay method with E.L.I.S.A. with determination after division I.C.C. of HBsAg by R.I.A. method in 33 cases of HBsAg negative acute viral hepatitis. The 9% (3 cases) were HAV acute hepatitis, the 42,4% (14 cases) no A no B acute hepatitis, the 36,3% (12 case) were HBV acute hepatitis, in 9 anti HBcAg positive cases the I.C.C. with HBsAg positive after division resulted positive, the 12,3% (4 cases) had a positivity for HAVab by stereoconversion (2 cases) or HAVab IgM (2 cases) with HBsAg positivity after division I.C.C. This result puts a nosologic problem about the 4 cases of acute viral hepatitis, which, from epidemiological and clinical point of the view are HAV acute hepatitis.
作者采用放射免疫分析法（R.I.A.）检测了乙肝病毒标志物（HBsAg、抗HBsAg、HBeAg、抗HBeAg、抗HBcAg）、甲肝病毒标志物（通过检测两份甲肝抗体样本或检测甲肝抗体IgM），采用C1q固相结合分析法结合酶联免疫吸附测定法（E.L.I.S.A.）检测免疫复合物（I.C.C.），并在33例HBsAg阴性急性病毒性肝炎患者中，通过放射免疫分析法对I.C.C.中的HBsAg进行检测。其中，9%（3例）为甲型肝炎急性肝炎，42.4%（14例）为非甲非乙型急性肝炎，36.3%（12例）为乙型肝炎急性肝炎，在9例抗HBcAg阳性病例中，分离后I.C.C.与HBsAg阳性结果呈阳性，12.3%（4例）通过立体转化（2例）或甲肝抗体IgM（2例）检测出甲肝抗体阳性，且分离后I.C.C.中HBsAg呈阳性。这一结果提出了一个关于4例急性病毒性肝炎的疾病分类问题，从流行病学和临床角度来看，这些病例应为甲型肝炎急性肝炎。
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