Siegmeth W, Placheta P
Schweiz Med Wochenschr. 1978 Mar 4;108(9):349-53.
Two non-steroidal antirheumatic drugs, diclofenac (Voltaren) and naproxen (Proxen), were compared with respect to their analgesic effect and the observed improvement in joint mobility in two groups of patients, each consisting of 20 males with either cox-arthrosis or gonarthrosis. The duration of treatment was up to six months. The therapeutic response was assessed by the mean scores of spontaneous and exercise-induced pain, the clinical state of joints and painfree time of walking. Both drugs led to a persistent improvement in the condition of most patients, but the clinical impression would appear to point to a more marked analgesic effect of diclofenac. The daily maintenance dosage from the fourth week of treatment onwards was 75 mg diclofenac and 500 mg naproxen. Both drugs were generally well tolerated. Occasionally gastrointestinal side effects were observed (more frequently in the naproxen group). Laboratory controls were carried out periodically, but no evidence of organ toxicity or hemotoxic effects was found.
在两组患者中比较了两种非甾体类抗风湿药物双氯芬酸（扶他林）和萘普生（甲氧萘丙酸）的镇痛效果以及观察到的关节活动度改善情况。每组由20名患有髋关节炎或膝关节炎的男性组成。治疗持续时间长达6个月。通过自发疼痛和运动诱发疼痛的平均评分、关节的临床状态以及无痛行走时间来评估治疗反应。两种药物都使大多数患者的病情持续改善，但临床印象似乎表明双氯芬酸的镇痛效果更显著。从治疗第四周起，每日维持剂量为双氯芬酸75毫克和萘普生500毫克。两种药物总体耐受性良好。偶尔观察到胃肠道副作用（在萘普生组中更常见）。定期进行实验室检查，但未发现器官毒性或血液毒性作用的证据。
