Siraux P
J Int Med Res. 1977;5(3):169-74. doi: 10.1177/030006057700500305.
A double-blind, between-patient, comparative trial of diclofenac (Voltaren) and naproxen was carried out in 30 patients suffering from osteo-arthrosis of the hip or the knee. The drugs were given twice daily, morning and evening, during a period of two weeks. The daily dose was 100 mg for Voltaren and 500 mg for naproxen. The results indicate that Voltaren brought relief of pain and stiffness in a greater number of patients than did naproxen. The same finding was made regarding the influence on the range of joint movements, the difference reaching statistical significance. Voltaren appeared also to be better tolerated since the number of patients reporting side-effects was smaller and the complaints of less severity.
对30例髋或膝骨关节炎患者进行了双盲、患者间比较试验，比较双氯芬酸（扶他林）和萘普生。药物在两周内每天早晚各服用一次。扶他林的日剂量为100毫克，萘普生为500毫克。结果表明，与萘普生相比，扶他林能使更多患者的疼痛和僵硬得到缓解。在对关节活动范围的影响方面也有相同的发现，差异具有统计学意义。扶他林的耐受性似乎也更好，因为报告副作用的患者数量较少，且症状较轻。
