Petrova E A, Lazareva N P, Khudadov G D
Vopr Med Khim. 1980 May-Jun;26(3):325-8.
Within 4 hrs after intravenous administration into rats of cholecalciferol maximal concentration of the compound, which was increased depending on the dose used, was found in liver tissue, within 24 hrs--in kidney. Increase in cholecalciferol doses led to an increase in the ratio of the esterified compound to its free form. Content of the esterified cholecalciferol reached the highest level in kidney within 4 hrs and 24 hrs after administration of all the doses of cholecalciferol studied.
给大鼠静脉注射胆钙化醇后4小时内，肝脏组织中发现该化合物的最大浓度，且其随所用剂量增加而升高；24小时内，肾脏中出现最大浓度。胆钙化醇剂量的增加导致酯化化合物与其游离形式的比例增加。在所研究的所有剂量的胆钙化醇给药后4小时和24小时内，酯化胆钙化醇的含量在肾脏中达到最高水平。
