Trimble B K, Baird P A
Teratology. 1978 Feb;17(1):43-9. doi: 10.1002/tera.1420170111.
The records of an ongoing health surveillance registry that utilizes multiple sources of ascertainment were used to study the incidence rates of congenital malformations of the central nervous system in children born in British Columbia during the period 1952-72. No overall increase in incidence rate of these anomalies was detected over the study period and the total frequency ascertained was three per thousand births. For anencephaly, spina bifida, hydrocephaly, and other CNS anomalies, the estimated incidence rates per 1,000 births are 0.6, 0.8, 1.0 and 0.5 respectively. A greater incidence rate or neural tube closure defects was found in females than in males and this difference was most marked amongst the stillbirths. The data indicate that multiple sources of ascertainment and follow-up of children beyond one year after birth are necessary for adequate reporting even for these sorts of defects which have generally been though to be readily recognized at or shortly after birth.
利用多种确诊来源的一个正在进行的健康监测登记处的记录，被用于研究1952年至1972年期间在不列颠哥伦比亚省出生儿童中枢神经系统先天性畸形的发病率。在研究期间未检测到这些异常的发病率总体上升，确诊的总频率为每千例出生3例。对于无脑儿、脊柱裂、脑积水和其他中枢神经系统异常，每1000例出生的估计发病率分别为0.6、0.8、1.0和0.5。发现女性神经管闭合缺陷的发病率高于男性，这种差异在死产中最为明显。数据表明，即使对于这类通常被认为在出生时或出生后不久就能轻易识别的缺陷，为了进行充分报告，对出生后一年以上的儿童进行多种确诊来源和随访也是必要的。
