Prytkov A N
Genetika. 1978 Aug;14(8):1461-5.
A sample investigation was carried out in 14 maternity homes of Moscow during 1970--1976 in order to determine the population incidence of defects of the neural tibe. Among 282336 newborns 220 probands with these anomalies were found including 11 with syndromes of non-multifactorial etiology. The total incidence of multifactorial forms was 0.74 +/- 0.10 per 1000 newborns, the incidence of the anencephaly was 0.33 +/- 0.07% and the frequency of the spina bifida was 0.41 +/- 0.07% respectively. The sex ratio 0.61 among probands was statistically significantly different from that normal among newborns. An insignificant increase of the incidence of the defects was observed during the autumn and winter seasons. No correlation was observed between the mother's age, the birth order and the incidence of the neural tube defects.
1970年至1976年期间，在莫斯科的14家妇产医院进行了一项抽样调查，以确定神经管缺陷在人群中的发病率。在282336名新生儿中，发现了220名患有这些异常的先证者，其中11名患有非多因素病因综合征。多因素形式的总发病率为每1000名新生儿0.74±0.10，无脑儿的发病率为0.33±0.07%，脊柱裂的发生率分别为0.41±0.07%。先证者中的性别比为0.61，与新生儿中的正常性别比有统计学显著差异。在秋冬季节观察到缺陷发生率有不显著的增加。未观察到母亲年龄、生育顺序与神经管缺陷发生率之间的相关性。
