头孢唑啉诱发的实验性癫痫：地西泮对发作间期脑电图的影响。
Cefazolin experimental epilepsy: the effects of diazepam on the interictal ECoG.
作者信息
Gallitto G, Musolino R, Troilo G, Bianchi L, Silvestri R, Di Perri R
出版信息
Boll Soc Ital Biol Sper. 1980 Oct 15;56(19):1996-2000.
PMID:6257261
Abstract
Diazepam i.v. injected at the dose of 5 mg/Kg on a group of 14 Rhode-Island-Red chicks was able to antagonize and prevent the interictal EEG pattern induced by cefazolin i.v. Since cefazolin epilepsy is most probably dependent on a receptorial antagonism with GABA, these data seem to confirm the GABA-ergic nature of cefazolin epilepsy.
摘要
给一组14只罗德岛红鸡静脉注射剂量为5毫克/千克的地西泮，能够对抗并预防静脉注射头孢唑林所诱发的发作间期脑电图模式。由于头孢唑林诱发的癫痫很可能依赖于与γ-氨基丁酸（GABA）的受体拮抗作用，这些数据似乎证实了头孢唑林诱发癫痫的GABA能性质。
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