经典抗癫痫药和丙戊酸钠对大鼠实验性癫痫中头孢唑林的拮抗作用。

Antagonism by classical antiepileptics and sodium valproate of cefazolin in induced experimental epilepsy in rats.

作者信息

Nistico G, De Sarro G B, Rotiroti D, Silvestri R, Marmo E

出版信息

Res Commun Chem Pathol Pharmacol. 1980 Sep;29(3):429-44.

Abstract

The effects of cefazolin, a semisynthetic cephalosporin, on rat behavior, electrocortical activity and on electrocortical spectrum power were evaluated. In addition, the possible antagonism by some antiepileptic agents was studied. Cegazolin, given intravenously in rats, produced generalized convulsions, electrocortical high-voltage spikes and other electrocortical abnormalities similar to those described to occur in human epilepsy. Power spectrum analysis of the electrocortical activity revealed a significant increase in total voltage output during electrocortical epileptogenic discharges. In addition high-voltage spikes induced by cefazolin were easily counted and lasted approximately 90 min. Classical antiepileptic drugs (diphenylhydantoin, phenobarbital and clonazepam as well as sodium valproate were able to counteract electroclinical disorders induced by cefazolin.

摘要

评估了半合成头孢菌素头孢唑林对大鼠行为、皮层电活动及皮层电图频谱功率的影响。此外，还研究了一些抗癫痫药物可能存在的拮抗作用。给大鼠静脉注射头孢唑林后，出现了全身性惊厥、皮层电活动高压棘波及其他类似于人类癫痫中所描述的皮层电活动异常。皮层电活动的功率谱分析显示，在皮层电活动致痫放电期间，总电压输出显著增加。此外，头孢唑林诱导的高压棘波易于计数，且持续约90分钟。经典抗癫痫药物（苯妥英、苯巴比妥、氯硝西泮以及丙戊酸钠）能够对抗头孢唑林诱发的电临床紊乱。