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[交感神经影响和环磷酸腺苷在味觉感受器装置离心抑制控制中的可能作用]

[Possible role of sympathetic influences and cAMP in centrifugal inhibitory control of the gustatory receptor apparatus].

作者信息

Esakov A I, Serova O N

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1980 Dec;66(12):1778-84.

PMID:6257563
Abstract

The electrophysiological analysis of the taste total impulse activity of the rat revealed the inhibitory influence of the gastric distention on the salt and sour taste responses to be decreased by cutting of the neck sympathetic nerve and prevented by the propranolol injection into the taste epithelium. Salt and sour taste responses were diminished by the injection of isoproterenol, cAMP, dibutyril--cAMP, and the inhibitors fo phosphodiesterase theophilline and paraverine; the activator of phosphodiesterase nicotine acid increased the taste responses. The finding suggest that the adrenergic transmitters and cAMP take part in the actualization of the inhibitory centrifugal influences.

摘要

对大鼠味觉总冲动活动的电生理分析显示,胃扩张对盐味和酸味反应的抑制作用在切断颈交感神经后减弱,并可通过向味觉上皮注射普萘洛尔来预防。注射异丙肾上腺素、环磷酸腺苷(cAMP)、二丁酰环磷酸腺苷(dibutyril - cAMP)以及磷酸二酯酶抑制剂茶碱和罂粟碱可使盐味和酸味反应减弱;磷酸二酯酶激活剂烟酸则可增强味觉反应。这些发现表明,肾上腺素能递质和环磷酸腺苷参与了抑制性离心影响的实现。

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