Camilleri M, Cooper B T, Adrian T E, Bloom S R, Chadwick V S
Gut. 1981 Jan;22(1):14-8. doi: 10.1136/gut.22.1.14.
The effects of porcine vasoactive intestinal peptide (VIP) and bovine pancreatic polypeptide (PP) on jejunal, ileal, and colonic fluid transport were studied in the rabbit. VIP produced secretion in the small intestine (jejunum greater than ileum) but did not affect absorption in the colon. PP had no secretory effects in jejunum, ileum, or colon. The small intestinal secretion induced by VIP was not associated with raised cAMP concentrations in the mucosa; this suggests that the secretory effects of VIP in vivo are mediated by a mechanism other than stimulation of adenylate cyclase.
在兔子身上研究了猪血管活性肠肽(VIP)和牛胰多肽(PP)对空肠、回肠和结肠液体转运的影响。VIP可使小肠(空肠大于回肠)分泌,但不影响结肠的吸收。PP对空肠、回肠或结肠没有分泌作用。VIP诱导的小肠分泌与黏膜中cAMP浓度升高无关;这表明VIP在体内的分泌作用是由刺激腺苷酸环化酶以外的机制介导的。