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1
Measurement of fasting and postprandial plasma VIP in man.人体空腹和餐后血浆血管活性肠肽的测量。
Gut. 1978 Nov;19(11):1043-8. doi: 10.1136/gut.19.11.1043.
2
Radioimmunoassay of vasoactive intestinal polypeptide (VIP) in plasma.血浆中血管活性肠肽（VIP）的放射免疫测定
J Lab Clin Med. 1977 Jun;89(6):1379-88.
3
The effect of a test meal on plasma vasoactive intestinal polypeptide (VIP), gastric inhibitory polypeptide (GIP), and secretin in man.试餐对人体血浆血管活性肠肽（VIP）、胃抑制性多肽（GIP）和促胰液素的影响。
Scand J Gastroenterol. 1979;14(8):939-43.
4
Radioimmunoassay of vasoactive intestinal polypeptide in plasma.血浆中血管活性肠肽的放射免疫测定
Scand J Gastroenterol. 1978;13(7):807-13. doi: 10.3109/00365527809182195.
5
Radioimmunoassay for vasoactive intestinal polypeptide (VIP) in plasma before and during endoscopic examinations.内镜检查前及检查期间血浆中血管活性肠肽（VIP）的放射免疫测定。
Hepatogastroenterology. 1982 Aug;29(4):146-50.
6
Fasting and prolonged exercise increase vasoactive intestinal polypeptide (VIP) in plasma.禁食和长时间运动可增加血浆中的血管活性肠肽（VIP）。
Acta Physiol Scand. 1979 Mar;105(3):374-7. doi: 10.1111/j.1748-1716.1979.tb06353.x.
7
Vasoactive intestinal peptide (VIP) in preterm and term neonates.早产和足月新生儿体内的血管活性肠肽（VIP）
Acta Paediatr Scand. 1982 Jan;71(1):71-4. doi: 10.1111/j.1651-2227.1982.tb09373.x.
8
Influence of meal composition on postprandial peripheral plasma concentrations of vasoactive peptides in man.膳食组成对人体餐后外周血浆中血管活性肽浓度的影响。
Scand J Clin Lab Invest. 1996 Oct;56(6):497-503. doi: 10.3109/00365519609088805.
9
Vasoactive intestinal polypeptide (VIP) in children with neural crest tumours.患有神经嵴肿瘤儿童体内的血管活性肠肽（VIP）
Acta Paediatr Scand. 1982 Sep;71(5):721-5. doi: 10.1111/j.1651-2227.1982.tb09510.x.
10
[Vasoactive intestinal peptide (VIP) in the Verner-Morrison syndrome (author's transl)].韦纳-莫里森综合征中的血管活性肠肽（作者译）
Nouv Presse Med. 1979 Apr 21;8(18):1505-8.

引用本文的文献

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Frequency and Causes of False-Positive Elevated Plasma Concentrations of Fasting Gut Hormones in a Specialist Neuroendocrine Tumor Center.在一家神经内分泌肿瘤专科中心，空腹肠激素血浓度升高的假阳性频率和原因。
Front Endocrinol (Lausanne). 2020 Dec 16;11:606264. doi: 10.3389/fendo.2020.606264. eCollection 2020.
2
Cholera and Pancreatic Cholera: Is VIP the Common Pathophysiologic Factor?霍乱与胰性霍乱：血管活性肠肽是共同的病理生理因素吗？
Trop Med Infect Dis. 2020 Jul 2;5(3):111. doi: 10.3390/tropicalmed5030111.
3
Homeostatic and therapeutic roles of VIP in smooth muscle function: myo-neuroimmune interactions.VIP 在平滑肌功能中的稳态和治疗作用：肌神经免疫相互作用。
Am J Physiol Gastrointest Liver Physiol. 2009 Oct;297(4):G716-25. doi: 10.1152/ajpgi.00194.2009. Epub 2009 Aug 6.
4
Gene therapy of Cav1.2 channel with VIP and VIP receptor agonists and antagonists: a novel approach to designing promotility and antimotility agents.采用血管活性肠肽及其受体激动剂和拮抗剂对Cav1.2通道进行基因治疗：设计促动力和抗动力药物的新方法。
Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G187-G196. doi: 10.1152/ajpgi.00047.2008. Epub 2008 May 8.
5
Functional coupling between nitric oxide synthesis and VIP release within enteric nerve terminals of the rat: involvement of protein kinase G and phosphodiesterase 5.大鼠肠神经末梢内一氧化氮合成与血管活性肠肽释放之间的功能偶联：蛋白激酶G和磷酸二酯酶5的作用
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6
Colonic responses to enteral tube feeding.结肠对肠内管饲的反应。
Gut. 1998 Feb;42(2):147-51. doi: 10.1136/gut.42.2.147.
7
The differential distribution of vasoactive intestinal polypeptide in the normal human female genital tract.血管活性肠肽在正常女性生殖道中的差异分布。
Histochemistry. 1980;67(2):169-77. doi: 10.1007/BF00493234.
8
Separation of the gut hormone endocrine-cell storage granules of human jejunum using analytical subcellular fractionation.利用分析性亚细胞分级分离法分离人空肠的肠激素内分泌细胞储存颗粒。
Gut. 1980 Mar;21(3):177-80. doi: 10.1136/gut.21.3.177.
9
Vasoactive intestinal peptide in relation to atropine resistant vasodilatation in the submaxillary gland of the cat.猫颌下腺中血管活性肠肽与阿托品抵抗性血管舒张的关系
J Physiol. 1980 Mar;300:41-53. doi: 10.1113/jphysiol.1980.sp013150.
10
VIP in the rat brain: evidence for a major pathway linking the amygdala and hypothalamus via the stria terminalis.大鼠脑中的血管活性肠肽：通过终纹床核连接杏仁核和下丘脑的主要通路的证据。
Histochemistry. 1980 Feb;65(2):103-19. doi: 10.1007/BF00493159.

本文引用的文献

1
Polypeptide with broad biological activity: isolation from small intestine.具有广泛生物活性的多肽：从小肠中分离得到。
Science. 1970 Sep 18;169(3951):1217-8. doi: 10.1126/science.169.3951.1217.
2
Intestinal secretion: stimulation by peptides.肠分泌：肽类的刺激作用。
Science. 1971 Oct 22;174(4007):422-4. doi: 10.1126/science.174.4007.422.
3
Isolation from porcine-intestinal wall of a vasoactive octacosapeptide related to secretin and to glucagon.从猪肠壁中分离出一种与促胰液素和胰高血糖素相关的血管活性二十八肽。
Eur J Biochem. 1972 Jul 13;28(2):199-204. doi: 10.1111/j.1432-1033.1972.tb01903.x.
4
Hyperglycemic and glycogenolytic effects of vasoactive intestinal polypeptide.血管活性肠肽的高血糖和糖原分解作用。
Proc Soc Exp Biol Med. 1973 Mar;142(3):1014-7. doi: 10.3181/00379727-142-37165.
5
Biological activities of synthetic peptides corresponding to fragments of and to the entire sequence of the vasoactive intestinal peptide.与血管活性肠肽片段及整个序列对应的合成肽的生物活性。
Proc Natl Acad Sci U S A. 1973 Feb;70(2):382-4. doi: 10.1073/pnas.70.2.382.
6
Vasoactive intestinal peptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa.血管活性肠肽对肠黏膜中腺苷酸环化酶的刺激作用及活性电解质分泌
J Clin Invest. 1974 Sep;54(3):536-44. doi: 10.1172/JCI107790.
7
Proceedings: The distribution of vasoactive intestinal peptide (VIP) in the primate gastrointestinal tract and characterization of VIP from human tumours.论文集：血管活性肠肽（VIP）在灵长类动物胃肠道中的分布及人肿瘤中VIP的特性
Gut. 1973 Oct;14(10):823.
8
Vasoactive intestinal peptide and watery-diarrhoea syndrome.血管活性肠肽与水样腹泻综合征
Lancet. 1973 Jul 7;2(7819):14-6. doi: 10.1016/s0140-6736(73)91947-8.
9
Structure of the vasoactive intestinal octacosapeptide from chicken intestine. The amino acid sequence.来自鸡肠道的血管活性肠二十八肽的结构。氨基酸序列。
FEBS Lett. 1975 Dec 15;60(2):322-6. doi: 10.1016/0014-5793(75)80740-x.
10
Current problems in the measurement of gastrin release. A reproducible measure of physiological gastrin release.胃泌素释放测量中的当前问题。生理胃泌素释放的可重复测量方法。
Postgrad Med J. 1976 Oct;52(612):645-50. doi: 10.1136/pgmj.52.612.645.

人体空腹和餐后血浆血管活性肠肽的测量。

Measurement of fasting and postprandial plasma VIP in man.

作者信息

Mitchell S J, Bloom S R

出版信息

Gut. 1978 Nov;19(11):1043-8. doi: 10.1136/gut.19.11.1043.

DOI:10.1136/gut.19.11.1043
PMID:730071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1412230/
Abstract

A specific radioimmunoassay has been developed capable of detecting 1.5 pmol VIP/l plasma with 95% confidence. The antisera employed reacted most avidly with whole VIP, partly with C terminal, but not with N terminal fragments. In 110 healthy fasting volunteers plasma VIP concentrations were estimated to lie between 0.5 and 21 pmol/l (median 1.7). No significant change was seen after ingestion of a standard test meal.

摘要

已开发出一种特异性放射免疫测定法，能够以95%的置信度检测血浆中1.5皮摩尔/升的血管活性肠肽（VIP）。所使用的抗血清与完整的VIP反应最强烈，部分与C末端反应，但不与N末端片段反应。在110名健康空腹志愿者中，血浆VIP浓度估计在0.5至21皮摩尔/升之间（中位数为1.7）。摄入标准测试餐后未见明显变化。