Feenstra L, van der Ven B W, Kohn F E, Feijen J
Int J Artif Organs. 1980 Nov;3(6):354-7.
Artificial eardrums made from biodegradable poly(D,L-lactic acid), poly(glycolic acid) and poly(beta-benzyl-L-aspartate-co-L-leucine) 50/50, and made from the microporous poly(tetrafluoroethylene) and bisphenol-A poly(carbonate) membranes were implanted into the ear and as a reference subcutaneously in rats. The implants were histologically examined for periods up to one year. From the biodegradable polymers studied the poly(beta-benzyl-L-aspartate-co-L-leucine) 50/50 evoked the least tissue reaction and the newly formed tympanic membranes are the best in terms of thickness and overall integrity. The microporous poly(tetrafluoroethylene) membrane can be considered as a valuable support for the formation of a reinforced tympanic membrane.
将由可生物降解的聚（D，L-乳酸）、聚乙醇酸和50/50的聚（β-苄基-L-天冬氨酸-co-L-亮氨酸）制成的人工耳膜，以及由微孔聚四氟乙烯和双酚A聚碳酸酯膜制成的人工耳膜植入大鼠耳部，并在皮下作为对照。对植入物进行长达一年的组织学检查。在所研究的可生物降解聚合物中，50/50的聚（β-苄基-L-天冬氨酸-co-L-亮氨酸）引起的组织反应最小，新形成的鼓膜在厚度和整体完整性方面是最好的。微孔聚四氟乙烯膜可被视为形成强化鼓膜的有价值的支撑物。
