Trousdale M D, Nesburn A B, Miller C A
Invest Ophthalmol Vis Sci. 1981 Feb;20(2):230-5.
Effects of topical acyclovir treatment on rabbit eyes infected with parent McKrae, idoxuridine-resistant, and vidarabine-resistant strains of HSV-1 were studied. Topical acyclovir therapy given four times a day was significantly more effective than idoxuridine and vidarabine at suppressing acute herpetic ocular disease induced by either sensitive or drug-resistant strains of HSV-1. Virus isolation from neural tissues indicated that none of the therapy prevented viral infection of the nervous system.
研究了局部应用阿昔洛韦治疗感染亲本McKrae、对碘苷耐药和对阿糖腺苷耐药的单纯疱疹病毒1型（HSV-1）毒株的兔眼的效果。每天给予4次局部阿昔洛韦治疗，在抑制由HSV-1敏感或耐药毒株引起的急性疱疹性眼病方面，比碘苷和阿糖腺苷显著更有效。从神经组织中分离病毒表明，没有一种治疗方法能预防神经系统的病毒感染。
