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阿昔洛韦对兔眼实验性单纯疱疹性角膜炎的治疗

Acyclovir treatment of experimental herpetic keratitis in the rabbit eye.

作者信息

Bauer D J

出版信息

Am J Med. 1982 Jul 20;73(1A):109-11. doi: 10.1016/0002-9343(82)90074-2.

DOI:10.1016/0002-9343(82)90074-2
PMID:7102698
Abstract

In the rabbit eye model of experimental herpetic keratitis a satisfactory cure was obtained with ointments containing 1 percent, 2 percent, and 3 percent acyclovir, and also with idoxuridine. Trifluorothymidine and vidarabine were less effective in the particular conditions of the experiment. A cure was also obtained with acyclovir sodium salt injected intravenously, thus demonstrating that a local infection of the eye can be treated systematically.

摘要

在兔实验性疱疹性角膜炎模型中,含1%、2%和3%阿昔洛韦的眼膏以及碘苷均可取得满意的治疗效果。在该实验的特定条件下,三氟胸腺嘧啶核苷和阿糖腺苷的效果较差。静脉注射阿昔洛韦钠盐也可治愈,这表明眼部局部感染可用全身治疗方法。

相似文献

1
Acyclovir treatment of experimental herpetic keratitis in the rabbit eye.阿昔洛韦对兔眼实验性单纯疱疹性角膜炎的治疗
Am J Med. 1982 Jul 20;73(1A):109-11. doi: 10.1016/0002-9343(82)90074-2.
2
Assessment of acyclovir on acute ocular infection induced by drug-resistant strains of HSV-1.阿昔洛韦对耐药性单纯疱疹病毒1型菌株引起的急性眼部感染的评估。
Invest Ophthalmol Vis Sci. 1981 Feb;20(2):230-5.
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Evaluation of the antiherpetic activity of acyclovir in rabbits.
Am J Med. 1982 Jul 20;73(1A):155-60. doi: 10.1016/0002-9343(82)90082-1.
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Acyclovir and vidarabine for the treatment of herpes simplex keratitis.阿昔洛韦和阿糖腺苷治疗单纯疱疹性角膜炎。
Am J Med. 1982 Jul 20;73(1A):281-5. doi: 10.1016/0002-9343(82)90106-1.
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[Treatment of experimental herpetic keratitis in rabbits with acycloguanosine (author's transl)].用阿昔洛韦治疗兔实验性疱疹性角膜炎(作者译)
Pathol Biol (Paris). 1981 Jan;29(1):43-5.
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[Chemotherapeutic activity of bonafton in experimental herpetic keratitis in rabbits].[波纳夫顿对兔实验性疱疹性角膜炎的化疗活性]
Farmakol Toksikol. 1975 Nov-Dec;38(6):728-32.
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Treatment of experimental herpes simplex keratitis with acycloguanosine.用阿昔洛韦治疗实验性单纯疱疹性角膜炎。
Br J Ophthalmol. 1979 Jun;63(6):429-35. doi: 10.1136/bjo.63.6.429.
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Anti-metabolites in the management of herpes simplex keratitis.抗代谢药物在单纯疱疹性角膜炎治疗中的应用
Metab Pediatr Ophthalmol. 1980;4(4):175-7.
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[Comparison of therapeutic activity of idoxuridine and acyclovir in experimentally-induced herpetic keratitis in rabbits (author's transl)].碘苷与阿昔洛韦对兔实验性疱疹性角膜炎治疗活性的比较(作者译)
J Fr Ophtalmol. 1981;4(1):33-43.
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A comparison of acyclovir and idoxuridine as treatment for ulcerative herpetic keratitis.阿昔洛韦与碘苷治疗溃疡性疱疹性角膜炎的比较。
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