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2
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Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice.阿昔洛韦与阿糖腺苷或其5'-单磷酸酯联合使用对细胞培养物和小鼠中单纯疱疹病毒的影响。
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本文引用的文献

1
Uptake, distribution, and anabolism of acyclovir in herpes simplex virus-infected mice.阿昔洛韦在单纯疱疹病毒感染小鼠体内的摄取、分布及合成代谢
Antimicrob Agents Chemother. 1982 Jan;21(1):44-50. doi: 10.1128/AAC.21.1.44.
2
Therapeutic activities of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus.1-(2-氟-2-脱氧-β-D-阿拉伯呋喃糖基)-5-碘胞嘧啶和-胸腺嘧啶单独及与阿昔洛韦和阿糖腺苷联合对脑内感染单纯疱疹病毒小鼠的治疗活性
Antimicrob Agents Chemother. 1983 Jul;24(1):95-103. doi: 10.1128/AAC.24.1.95.
3
Intracerebral inoculation of newborn and adult mice with thymidine kinase-deficient mutants of herpes simplex virus type 1.
J Infect Dis. 1983 May;147(5):956. doi: 10.1093/infdis/147.5.956.
4
Comparative neurovirulence of herpes simplex virus type 1 strains after peripheral or intracerebral inoculation of BALB/c mice.1型单纯疱疹病毒株经外周或脑内接种BALB/c小鼠后的比较神经毒力
Infect Immun. 1983 Apr;40(1):103-12. doi: 10.1128/iai.40.1.103-112.1983.
5
Virus-induced thymidine kinases as markers for typing herpes simplex viruses and for drug sensitivity assays.病毒诱导的胸苷激酶作为单纯疱疹病毒分型及药敏试验的标志物。
J Virol Methods. 1982 Nov;5(3-4):209-17. doi: 10.1016/0166-0934(82)90011-8.
6
Assessment of acyclovir on acute ocular infection induced by drug-resistant strains of HSV-1.阿昔洛韦对耐药性单纯疱疹病毒1型菌株引起的急性眼部感染的评估。
Invest Ophthalmol Vis Sci. 1981 Feb;20(2):230-5.
7
Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo.单纯疱疹病毒株在体外和体内对阿昔洛韦耐药情况下在小鼠中的致病性。
Antimicrob Agents Chemother. 1980 Feb;17(2):209-16. doi: 10.1128/AAC.17.2.209.
8
Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice.阿昔洛韦与阿糖腺苷或其5'-单磷酸酯联合使用对细胞培养物和小鼠中单纯疱疹病毒的影响。
Antimicrob Agents Chemother. 1982 Sep;22(3):499-507. doi: 10.1128/AAC.22.3.499.
9
Antigenic and biologic differences in herpesvirus hominis.人疱疹病毒的抗原性和生物学差异。
Prog Med Virol. 1968;10:110-59.
10
Characterization of acyclovir-resistant and -sensitive herpes simplex viruses isolated from a patient with an acquired immune deficiency.从一名获得性免疫缺陷患者分离出的阿昔洛韦耐药和敏感单纯疱疹病毒的特征分析
J Antimicrob Chemother. 1986 Oct;18 Suppl B:127-34. doi: 10.1093/jac/18.supplement_b.127.

用于治疗感染耐阿昔洛韦单纯疱疹病毒小鼠的药物组合

Drug combinations for treatment of mice infected with acyclovir-resistant herpes simplex virus.

作者信息

Schinazi R F

出版信息

Antimicrob Agents Chemother. 1987 Mar;31(3):477-9. doi: 10.1128/AAC.31.3.477.

DOI:10.1128/AAC.31.3.477
PMID:3579265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174758/
Abstract

The purpose of this study was to determine whether acyclovir resistance in mice infected with herpes simplex virus could be overcome by using high doses of acyclovir or vidarabine alone or by using a combination of the two drugs. The results indicate that the mice infected intracerebrally were refractory to acyclovir alone but responded to vidarabine or a combination of vidarabine and acyclovir. These observations have major implications for the clinical management of severe herpetic infections, particularly if attempts are to be made to devise means of circumventing drug resistance.

摘要

本研究的目的是确定单纯疱疹病毒感染小鼠的阿昔洛韦耐药性能否通过单独使用高剂量阿昔洛韦或阿糖腺苷，或联合使用这两种药物来克服。结果表明，脑内感染的小鼠对单独使用阿昔洛韦无效，但对阿糖腺苷或阿糖腺苷与阿昔洛韦联合用药有反应。这些观察结果对严重疱疹感染的临床管理具有重要意义，特别是在试图设计规避耐药性方法的情况下。