用于治疗感染耐阿昔洛韦单纯疱疹病毒小鼠的药物组合
Drug combinations for treatment of mice infected with acyclovir-resistant herpes simplex virus.
作者信息
Schinazi R F
出版信息
Antimicrob Agents Chemother. 1987 Mar;31(3):477-9. doi: 10.1128/AAC.31.3.477.
Abstract
The purpose of this study was to determine whether acyclovir resistance in mice infected with herpes simplex virus could be overcome by using high doses of acyclovir or vidarabine alone or by using a combination of the two drugs. The results indicate that the mice infected intracerebrally were refractory to acyclovir alone but responded to vidarabine or a combination of vidarabine and acyclovir. These observations have major implications for the clinical management of severe herpetic infections, particularly if attempts are to be made to devise means of circumventing drug resistance.
摘要
本研究的目的是确定单纯疱疹病毒感染小鼠的阿昔洛韦耐药性能否通过单独使用高剂量阿昔洛韦或阿糖腺苷，或联合使用这两种药物来克服。结果表明，脑内感染的小鼠对单独使用阿昔洛韦无效，但对阿糖腺苷或阿糖腺苷与阿昔洛韦联合用药有反应。这些观察结果对严重疱疹感染的临床管理具有重要意义，特别是在试图设计规避耐药性方法的情况下。
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