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[关于放射治疗对恶性疾病患者外周淋巴细胞和肿瘤组织中DNA修复过程影响的研究(作者译)]

[Investigations of the influence of radiation therapy upon the course of the DNA repair in peripheric lymphocytes and tumorous tissues from patients with malignant disease (author's transl)].

作者信息

Alth G, Klein H, Koren H, Klein W

出版信息

Strahlentherapie. 1978 Jan;154(1):44-52.

PMID:625771
Abstract

The influence of radiation therapy upon the capacity of DNA repair in peripheric lymphocytes and tumorous tissues was studied in eleven patients with malignant manifestations. A comparison was made between the effects of short-term and of long-term irradiation. The individual cases presented differing results. An enhancement of DNA repair as well as a diminution was observed in peripheric lymphocytes as a response to irradiation. In tumorous tissues, on the contrary, a total inhibition of DNA repair was generally found.

摘要

对11例有恶性症状的患者研究了放射治疗对外周淋巴细胞和肿瘤组织中DNA修复能力的影响。对短期和长期照射的效果进行了比较。个别病例呈现出不同的结果。作为对辐射的反应,在外周淋巴细胞中观察到DNA修复增强以及减弱的情况。相反,在肿瘤组织中,通常发现DNA修复完全受到抑制。

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