Anderson G F, Sfakianakis G, King D R, Boles E T
J Pediatr Surg. 1980 Dec;15(6):900-5. doi: 10.1016/s0022-3468(80)80301-0.
A canine model simulating Meckel's diverticulum was used to evaluate the effects of pentagastrin, glucagon, and a combination of the two hormones on the gastrointestinal localization of 99mTc. Pentagastrin produced accelerated uptake of the radionuclide in both the stomach and the ectopic gastric mucosa but resulted in early visualization of the duodenum and a "washout" effect on the radioisotope within the Meckel's diverticulum. Glucagon provided prolonged retention of the radionuclide in the stomach and ectopic mucosa and prevented duodenal visualization. A combination of both hormones produced increased activity in the stomach and experimental Meckel's and decreased duodenal filling. This enhanced target to background contrast and provided improved visualization of the ectopic gastric mucosa.
使用一种模拟梅克尔憩室的犬类模型来评估五肽胃泌素、胰高血糖素以及这两种激素联合使用对99mTc在胃肠道定位的影响。五肽胃泌素使胃和异位胃黏膜中放射性核素的摄取加速，但导致十二指肠早期显影，并对梅克尔憩室内的放射性同位素产生“洗脱”效应。胰高血糖素使放射性核素在胃和异位黏膜中保留时间延长，并防止十二指肠显影。两种激素联合使用使胃和实验性梅克尔憩室内的活性增加，十二指肠充盈减少。这增强了靶与背景的对比度，改善了异位胃黏膜的显影效果。
