[血浆中游离色氨酸和总色氨酸的研究。其在精神病学中的价值]

[Study of free and total tryptophan in the plasma. It value in psychiatry].

作者信息

Deniker P, Lôo H, Zarifian E, Bousquet B, Dreux C, Escande C

出版信息

Encephale. 1976;2(2):123-32.

Abstract

The dosage of the whole tryptophan and of the free tryptophan was conducted in 16 normal subjects to establish reference values and in 12 schizophrenic subjects among whom 7 were under treatment and 5 were not. The method of dosage is made by spectrofluorimetry by increasing the native fluorescence of tryptophan. The results give mean values for the free tryptophan and for the ratio of the free tryptophan to the whole tryptophan values that are higher in the schizophrenics than in the normal subjects used as reference, while the whole tryptophan seems to be little modified ; this increase is more noticeable in the schizophrenics under treatment. The limited number of the cases studied does not enable us yet to establish correlations between the increase of the free tryptophan found in some cases and the nature of the schizophrenia, its age and its evolutivity or even the clinical response to the treatment. However, some figures for the free tryptophan being very much higher than the mean value in some schizophrenics, suggest ways of research for understanding the pathogenisis of schizophrenia and the mechanisms of the therapeutic action of the psychotropic drugs.

摘要

对16名正常受试者进行了全色氨酸和游离色氨酸的剂量测定以建立参考值，并对12名精神分裂症患者进行了测定，其中7名正在接受治疗，5名未接受治疗。剂量测定方法是通过增加色氨酸的天然荧光，采用荧光分光光度法。结果显示，精神分裂症患者的游离色氨酸平均值以及游离色氨酸与全色氨酸的比值均高于作为参考的正常受试者，而全色氨酸似乎变化不大；这种增加在接受治疗的精神分裂症患者中更为明显。所研究的病例数量有限，尚无法使我们在某些病例中发现的游离色氨酸增加与精神分裂症的性质、年龄、病程演变甚至治疗的临床反应之间建立相关性。然而，一些精神分裂症患者的游离色氨酸数值远高于平均值，这为理解精神分裂症的发病机制和精神药物治疗作用的机制提供了研究方向。