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[干扰素诱导复合物对小鼠全身X线照射后骨髓细胞DNA、RNA和蛋白质的胸腺嘧啶核苷3H标记的影响]

[Effect of interferon-inducing complex on thymidine 3H-labeling of DNA, RNA and proteins of marrow cells after total X-irradiation of mice].

作者信息

Ternovoĭ N K

出版信息

Ukr Biokhim Zh (1978). 1978 Jan-Feb;50(1):98-101.

PMID:625818
Abstract

Interferonogen is shown to intensify the RNA synthesis only slightly, practically having effect neither on DNA synthesis nor on protein one. Interferonogen administered 2h before irradiation impedes development of the pronounced inhibition of DNA, first of all. Basing on the fact that the mentioned regularities were manifested at the early stages of the post radiation period (up to 3-4 h) and coming from the previously established radioprojection efficiency of interferonogen it is supposed that interferonogenesis takes part in regulation of the cell reparation systems.

摘要

干扰素原仅略微增强RNA合成,实际上对DNA合成和蛋白质合成均无影响。在照射前2小时给予干扰素原首先会阻碍DNA明显抑制的发展。基于上述规律在辐射后早期阶段(直至3 - 4小时)就已显现,并且鉴于先前确定的干扰素原的放射投影效率,推测干扰素生成参与细胞修复系统的调节。

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