6-酮-前列腺素E1对人淋巴细胞环磷酸腺苷水平的影响。
The effect of 6-keto-prostaglandin E1 on human lymphocyte cAMP levels.
作者信息
Mastacchi R, Fadda S, Tomasi V, Barnabei O
出版信息
Prostaglandins Med. 1980 Dec;5(6):487-94. doi: 10.1016/0161-4630(80)90072-5.
PMID:6258185
Abstract
6-keto-PGE1 was capable of increasing cyclic AMP levels of peripheral human blood lymphocytes in a dose and time dependent fashion. The response was maximal after 30 min of incubation at 37 degrees C; 1 microgram per ml of 6-keto-PGE1 elevated cyclic AMP levels 5 fold which compares with a 10 fold increase due to PGE1. Thus 6-keto-PGE1 may play a role as a modulator of lymphocyte function.
摘要
6-酮-前列腺素E1能够以剂量和时间依赖性方式提高人外周血淋巴细胞的环磷酸腺苷水平。在37℃孵育30分钟后反应达到最大值；每毫升1微克的6-酮-前列腺素E1可使环磷酸腺苷水平升高5倍，而前列腺素E1可使其升高10倍。因此，6-酮-前列腺素E1可能作为淋巴细胞功能的调节剂发挥作用。
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