Bosher S K
Acta Otolaryngol. 1980 Sep-Oct;90(3-4):219-29. doi: 10.3109/00016488009131718.
The endolymphatic effects of perilymphatic ouabain (2 X 10(-3) M) were followed in 3 guinea pigs using ion-sensitive micro-electrodes, enabling a Na+-related permeability increase to be identified. Investigation of the strial ultrastructural changes in 11 more animals revealed early swelling of the marginal cells, while the intermediate and basal cells became shrunken with characteristically dark-staining cytoplasm. The subsequent cellular alterations were complex. The findings suggest that a major function of the Na+-K+-activated ATPase is preservation of the normal intracellular environment, inhibition resulting in widespread indirect effects. General measures of strial function, consequently, do not document just ATPase inhibition.
使用离子敏感微电极在3只豚鼠中观察了外淋巴哇巴因（2×10⁻³ M）对内淋巴的影响，从而确定了与钠相关的通透性增加。对另外11只动物的血管纹超微结构变化进行研究发现，边缘细胞早期肿胀，而中间细胞和基底细胞则皱缩，细胞质染色深。随后的细胞改变很复杂。这些发现表明，钠钾激活的ATP酶的主要功能是维持正常的细胞内环境，抑制该酶会导致广泛的间接影响。因此，血管纹功能的一般测量并不能仅证明ATP酶受到了抑制。
