Wackym P A, Glasscock M E, Linthicum F H, Friberg U, Rask-Andersen H
Division of Head and Neck Surgery, UCLA School of Medicine.
Arch Otorhinolaryngol. 1988;245(4):221-3. doi: 10.1007/BF00463931.
The presence and distribution of the transport protein complex Na+,K+-ATPase in the human endolymphatic sac (ES) was demonstrated immunohistochemically using a monoclonal antibody directed toward the denatured catalytic subunit of Na+,K+-ATPase from lamb kidney medulla. Our findings support an active transcellular ion exchange by the ES epithelium with subsequent passive transcellular and paracellular outflow of water. The possible role of the lateral intercellular spaces in the outflow of endolymph at the level of the ES is discussed.
利用针对羊肾髓质Na +，K + -ATP酶变性催化亚基的单克隆抗体，通过免疫组织化学方法证实了人内淋巴囊（ES）中转运蛋白复合物Na +，K + -ATP酶的存在和分布。我们的研究结果支持ES上皮细胞进行活跃的跨细胞离子交换，随后水通过跨细胞和细胞旁被动流出。讨论了细胞间侧间隙在ES水平内淋巴流出中的可能作用。
