Danse L H, Verschuren P M
Vet Pathol. 1978 Jan;15(1):114-24. doi: 10.1177/030098587801500113.
Yellow fat disease was induced in young rats given a vitamin E-deficient diet supplemented with 15% fish oil. The changes in adipose tissue of this oil-induced disorder were different from those of natural yellow fat disease in horse, pig and mink. In the natural disease all fat depots had the early stage of yellow fat disease with interstitial lipofuscin-laden macrophages exclusively. In the rat, however, this change was seen only in the subcutaneous fat depot. Moreover, affected adipose tissue of animals with natural disease had extensive fibrosis, but in the rat fibrosis was always absent. Rats with fish oil-induced yellow fat disease had degenerative changes in various fat depots that occurred at various times but in the horse, pig and mink fat depots were affected simultaneously. Lipofuscin accumulated in the reticuloendothelial system in rats. Accumulation in spleen and liver was dependent on vitamin E deficiency, but only the accumulation in the Kupffer cells was correlated with yellow fat disease. Lipofuscin accumulation in the mesenteric lymph node did not depend on vitamin E deficiency.
给幼鼠喂食缺乏维生素E并添加15%鱼油的饮食可诱发黄脂病。这种由鱼油诱发的疾病在脂肪组织中的变化不同于马、猪和貂的自然黄脂病。在自然疾病中，所有脂肪库都处于黄脂病早期，仅有间质中充满脂褐素的巨噬细胞。然而，在大鼠中，这种变化仅见于皮下脂肪库。此外，患自然疾病动物的受影响脂肪组织有广泛纤维化，但大鼠中始终不存在纤维化。鱼油诱发黄脂病的大鼠在不同脂肪库有退行性变化，这些变化在不同时间出现，但马、猪和貂的脂肪库同时受到影响。脂褐素在大鼠的网状内皮系统中蓄积。在脾脏和肝脏中的蓄积取决于维生素E缺乏，但仅库普弗细胞中的蓄积与黄脂病相关。肠系膜淋巴结中的脂褐素蓄积不取决于维生素E缺乏。
