Danse L H, Verschuren P M
Vet Pathol. 1978 Jul;15(4):544-8. doi: 10.1177/030098587801500412.
Basal and hormone-stimulated lipolysis of adipose tissue was measured at successive stages during the development of fish oil-induced yellow fat disease in rats. Changes of lipolytic activity at an early stage of yellow fat disease were not seen. There was a significant increase of basal lipolysis and a decrease of stimulated lipolysis when many fat cells were affected (stage E). Since the increased basal lipolysis probably originates from degenerated fat cells, the mechanism of enzyme activation is not clear. The decreased stimulated lipolysis was proportional to the number of affected fat cells and resulted from membrane damage of these cells. Increased 5-nucleotidase activity, seen in affected fat cells, may be important, to this reduced stimulated lipolysis.
在大鼠鱼油诱导的黄脂病发展的连续阶段，测量了脂肪组织的基础脂解和激素刺激的脂解。在黄脂病早期未观察到脂解活性的变化。当许多脂肪细胞受到影响时（E期），基础脂解显著增加，刺激脂解减少。由于基础脂解增加可能源于退化的脂肪细胞，酶激活机制尚不清楚。刺激脂解减少与受影响脂肪细胞的数量成比例，是由这些细胞的膜损伤导致的。在受影响的脂肪细胞中观察到的5-核苷酸酶活性增加，可能对这种刺激脂解减少很重要。
