Danse L H, Steenbergen-Botterweg W A
Vet Pathol. 1978 Jan;15(1):125-32. doi: 10.1177/030098587801500114.
Adipose tissue in various stages of fish oil-induced yellow fat disease in the rat had the same acid phosphatase and 5-nucleotidase activity pattern as similar stages of the disorder in mink and pig. A weak acid phosphatase and 5-nucleotidase activity was seen in interstitial lipofuscin-laden macrophages in "stage M" yellow fat disease without fat cell degeneration. Activity of these macrophagic enzymes increased when there was fat cell degeneration ("stage S" and "stage E" yellow fat disease). This different phosphatase activity in the same cell type may result from phagocytosis of substrates with variable digestibility. Macrophages directly surrounding affected fat cells in steatitis areas ("stage S" and "stage E") had strong acid phosphatase and 5-nucleotidase activity. As in the pig, increased 5-nucleotidase activity was found in affected fat cells, which probably indicates plasma membrane damage. Increased nonspecific esterase activity occurred around affected fat cells. Only a small part of this esterase activity originated from inflammatory cells. This indicates that an increase of esterase activity in degenerating adipose tissue may be an endogeneous process in this tissue.
大鼠鱼油诱导性黄脂病不同阶段的脂肪组织，其酸性磷酸酶和5-核苷酸酶活性模式与水貂和猪该病相似阶段的相同。在“M期”黄脂病无脂肪细胞变性的间质脂褐素 laden 巨噬细胞中可见弱酸性磷酸酶和5-核苷酸酶活性。当出现脂肪细胞变性时（“S期”和“E期”黄脂病），这些巨噬细胞酶的活性增加。同一细胞类型中这种不同的磷酸酶活性可能源于对消化率不同的底物的吞噬作用。脂肪炎区域（“S期”和“E期”）中直接围绕受影响脂肪细胞的巨噬细胞具有强酸性磷酸酶和5-核苷酸酶活性。与猪一样，在受影响的脂肪细胞中发现5-核苷酸酶活性增加，这可能表明质膜受损。受影响脂肪细胞周围出现非特异性酯酶活性增加。这种酯酶活性只有一小部分源自炎症细胞。这表明退化脂肪组织中酯酶活性的增加可能是该组织中的一个内源性过程。
