Pastore G, Angarano G, Pesce V, Dentico P, Schiraldi O
Boll Ist Sieroter Milan. 1980 Sep 30;59(4):331-7.
In a serological survey of 85 adult patients hospitalized for an episode of transfusion-associated hepatitis, 45 were reactive for hepatitis B surface antigen and therefore diagnosed as having hepatitis B. Forty HBsAg non reactive patients were examined for development of antibody to hepatitis A and B antigens, cytomegalovirus and Epstein-Barr virus. Three patients showed serologic evidence of hepatitis B and one for hepatitis A. None of the remaining 36 subjects developed serologic evidence of acute infection with the viruses tested during the study period, so that they were classified as having so-called NANB hepatitis. As reported in other studies, analysis of the incubation period showed that two subgroups of NANB hepatitis may be identified with short and long incubation period, so that it appears likely that at least two agents are implicated in NANB hepatitis. Our data confirm that also in our area a large proportion of transfusion-associated hepatitis is related to NANB agent(s) requiring additional measures for its prevention.
在一项针对85名因输血相关肝炎发作而住院的成年患者的血清学调查中，45名患者的乙肝表面抗原呈阳性反应，因此被诊断为患有乙型肝炎。对40名乙肝表面抗原无反应的患者进行了甲型和乙型肝炎抗原、巨细胞病毒和EB病毒抗体检测。3名患者显示有乙型肝炎的血清学证据，1名有甲型肝炎的证据。其余36名受试者在研究期间均未出现所检测病毒急性感染的血清学证据，因此他们被归类为患有所谓的非甲非乙型肝炎。正如其他研究报告的那样，对潜伏期的分析表明，非甲非乙型肝炎可分为潜伏期短和潜伏期长的两个亚组，因此看来至少有两种病原体与非甲非乙型肝炎有关。我们的数据证实，在我们所在地区，很大一部分输血相关肝炎与非甲非乙型病原体有关，需要采取额外的预防措施。
