豚鼠离体输精管中三磷酸腺苷与去甲肾上腺素之间的相互作用。
Interaction between adenosine triphosphate and noradrenaline in the isolated vas deferens of the guinea-pig.
作者信息
Kazić T, Milosavljević D
出版信息
Br J Pharmacol. 1980;71(1):93-8. doi: 10.1111/j.1476-5381.1980.tb10913.x.
Abstract
1 An interaction between adenosine triphosphate (ATP) and noradrenaline (NA) was investigated in the isolated vas deferens of the guinea-pig. 2 ATP (1.7 to 50 microM) enhanced contractions due to transmural electrical stimulation (ES; parameters: 30 Hz, 0.2 to 0.3 ms, 10 to 30 V; 1 s train duration). Responses to exogenous NA (12 microM) were also potentiated by ATP while contractions to acetylcholine (6 microM) were inhibited. 3 NA (1.2 microM) potentiated ATP-induced contractions and prevented the development of tachyphylaxis to ATP (510 microM). 4 Phentolamine (12.5 microM) prevented the potentiation by NA of ATP-induced contractions; these contractions were insensitive to phentolamine (up to 25 microM). 5 Removal of potassium chloride from the Tyrode solution for 10 min abolished the potentiating actions of both ATP and NA. 6 The present results suggest that the effect of ATP may be functionally closely related to that of NA at alpha-adrenoceptors in the vas deferens of the guinea-pig.
摘要
1 在豚鼠离体输精管中研究了三磷酸腺苷（ATP）与去甲肾上腺素（NA）之间的相互作用。2 ATP（1.7至50微摩尔）增强了经壁电刺激（ES；参数：30赫兹，0.2至0.3毫秒，10至30伏；1秒串刺激持续时间）引起的收缩。ATP还增强了对外源性NA（12微摩尔）的反应，而对乙酰胆碱（6微摩尔）的收缩则受到抑制。3 NA（1.2微摩尔）增强了ATP诱导的收缩，并防止了对ATP（5至10微摩尔）快速耐受性的发展。4 酚妥拉明（12.5微摩尔）阻止了NA对ATP诱导收缩的增强作用；这些收缩对酚妥拉明（高达25微摩尔）不敏感。5 从台氏液中去除氯化钾10分钟会消除ATP和NA的增强作用。6 目前的结果表明，在豚鼠输精管中，ATP的作用可能在功能上与NA在α-肾上腺素能受体上的作用密切相关。
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