Harding J W, Stone L P, Wright J W
Brain Res. 1981 Feb 2;205(2):265-74. doi: 10.1016/0006-8993(81)90338-3.
The distribution of specific angiotensin II (AII) binding capacity of several brain regions, pituitary, and adrenals was determined in 6 rodent species namely rats, mice, hamsters, kangaroo rats, gerbils and degus. Rats and mice had similar distributions with the highest levels of binding observed in the area postrema, septum and superior colliculi. Low levels were seen in the cortex, cerebellum, striatum and hippocampus. Other areas had intermediate levels. The distribution of AII binding in gerbils and degus was strikingly different from rats and mice. In these species, little or no binding could be detected in the brain. Additionally, the level of binding in degu adrenals was extremely low when compared to the binding observed in the adrenals of the other species. The distribution of AII binding sites in hamsters and kangaroo rats, although similar in some ways to rats and mice, had several major differences. Both had much higher levels of specific binding in cerebellum, striatum, and the hippocampus areas which had low levels of AII binding in rats an mice. Hamsters were the only species to exhibit significant specific binding in the cortex. The kangaroo rats had an unusual distribution of receptors with an apparent lack of specific binding in midbrain and area postrema.
在6种啮齿动物（即大鼠、小鼠、仓鼠、更格卢鼠、沙鼠和八齿鼠）中测定了几个脑区、垂体和肾上腺中特异性血管紧张素II（AII）结合能力的分布情况。大鼠和小鼠的分布相似，在最后区、隔区和上丘中观察到最高水平的结合。在皮质、小脑、纹状体和海马体中结合水平较低。其他区域的结合水平处于中等。沙鼠和八齿鼠中AII结合的分布与大鼠和小鼠明显不同。在这些物种中，在脑中几乎检测不到或检测不到结合。此外，与在其他物种肾上腺中观察到的结合相比，八齿鼠肾上腺中的结合水平极低。仓鼠和更格卢鼠中AII结合位点的分布虽然在某些方面与大鼠和小鼠相似，但也有几个主要差异。两者在小脑、纹状体和海马体区域的特异性结合水平都高得多，而这些区域在大鼠和小鼠中AII结合水平较低。仓鼠是唯一在皮质中表现出显著特异性结合的物种。更格卢鼠的受体分布异常，在中脑和最后区明显缺乏特异性结合。
