Walker J E, Mikeska J A, Crawford I L
Brain Res Bull. 1981 Jan;6(1):1-3. doi: 10.1016/s0361-9230(81)80062-7.
The basolateral amygdala of rats was stimulated once daily until three successive fully kindled seizures were elicited. Twenty-four hours after the last seizure the rats were sacrificed by focused microwave irradiation to the head. Tissues from homolateral and contralateral amygdala and cerebral cortex were assayed for cAMP and cGMP content. No significant changes in cyclic nucleotides were measured in the kindled animals. These studies indicate that long term changes in the steady-state level of total tissue cyclic nucleotides do not occur concomitant with the persistently altered excitability associated with kindling of the amygdala.
每天对大鼠的基底外侧杏仁核进行一次刺激，直到引发连续三次完全点燃的癫痫发作。在最后一次癫痫发作后24小时，通过对头进行聚焦微波照射处死大鼠。测定同侧和对侧杏仁核及大脑皮层组织中的环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）含量。在点燃的动物中未检测到环核苷酸的显著变化。这些研究表明，总组织环核苷酸稳态水平的长期变化不会与杏仁核点燃相关的持续改变的兴奋性同时发生。
