Lee N M, Leybin L, Chang J K, Loh H H
Eur J Pharmacol. 1980 Nov 21;68(2):181-5. doi: 10.1016/0014-2999(80)90319-2.
Interactions between the weakly analgesic enkephalins and morphine on morphine-induced analgesia were studied. Met-enkephalin exhibited morphine analgesia whereas Leu-enkephalin potentiated it. Both Met- and Leu-enkephalin, when tested alone, were not analgesic. The strongly analgesic FK33824 (Sandoz) compound, like Leu-enkephalin, also potentiated morphine analgesia. Tolerance developed to morphine analgesia but not to Met-enkephalin inhibition of morphine analgesia.
研究了弱镇痛性脑啡肽与吗啡对吗啡诱导镇痛的相互作用。甲硫氨酸脑啡肽表现出吗啡镇痛作用，而亮氨酸脑啡肽则增强了这种作用。单独测试时，甲硫氨酸脑啡肽和亮氨酸脑啡肽均无镇痛作用。强镇痛性化合物FK33824（山德士公司）与亮氨酸脑啡肽一样，也增强了吗啡镇痛作用。吗啡镇痛会产生耐受性，但甲硫氨酸脑啡肽对吗啡镇痛的抑制作用不会产生耐受性。
