Hom G J, Lokhandwala M F
Eur J Pharmacol. 1981 Jan 5;69(1):101-6. doi: 10.1016/0014-2999(81)90607-5.
Infusion of adenosine (1 mg/kg/min i.v.) to pentobarbital-anesthetized dogs resulted in a decrease in blood pressure and significant attenuation of the femoral vasoconstrictor responses to lumbar sympathetic nerve stimulation. The vasoconstrictor action of exogenous norepinephrine was unaltered during adenosine infusion. The inhibitory action of adenosine on responses to sympathetic nerve stimulation could be antagonized by theophylline (5 mg/kg i.v.), but not indomethacin (10 mg/kg i.v.). Additional experiments were performed to study the role of this sympathoinhibitory action of adenosine in the vasodilator effect of the compound. Intraarterial administration of adenosine produced dose related femoral vasodilatation. Sympathetic denervation of the femoral vascular bed did not alter the vasodilatory action of adenosine. Continuous lumbar sympathetic nerve stimulation or intraarterial norepinephrine infusion also did not change the vasodilatation produced by adenosine. The vasodilatory action of adenosine was antagonized by theophylline. These results suggest that adenosine causes inhibition of sympathetic neurotransmission to the femoral vasculature via an action on presynaptic purinergic receptors. However, this presynaptic inhibitory action of adenosine is not involved in the femoral vasodilatation produced by the compound.
向戊巴比妥麻醉的犬静脉输注腺苷（1毫克/千克/分钟）会导致血压下降，并显著减弱股动脉对腰交感神经刺激的血管收缩反应。在输注腺苷期间，外源性去甲肾上腺素的血管收缩作用未改变。腺苷对交感神经刺激反应的抑制作用可被茶碱（静脉注射5毫克/千克）拮抗，但不能被吲哚美辛（静脉注射10毫克/千克）拮抗。进行了额外的实验以研究腺苷这种交感神经抑制作用在该化合物血管舒张作用中的作用。动脉内给予腺苷会产生与剂量相关的股动脉血管舒张。股血管床的交感神经去支配并未改变腺苷的血管舒张作用。持续的腰交感神经刺激或动脉内输注去甲肾上腺素也未改变腺苷产生的血管舒张。腺苷的血管舒张作用被茶碱拮抗。这些结果表明，腺苷通过作用于突触前嘌呤能受体抑制对股血管系统的交感神经传递。然而，腺苷的这种突触前抑制作用并不参与该化合物产生的股动脉血管舒张。
