Vallier P, Farjanel J, Bata J, Deviller P
Experientia. 1981 Jan 15;37(1):21-3. doi: 10.1007/BF01965546.
In KB cells, MRC5 and adult skin fibroblasts infected by low doses of Sendaï virus, intracellular cyclic AMP levels rose and fell in the first hours following infection, then remained lower than basal level during at least 2 days in KB cells and adult skin fibroblasts. When compared to other viruses or cAMP inducers previously described, this effect appeared specific of Sendaï virus. Mechanisms and roles of cAMP variations are discussed. VSV-infected KB cells showed slightly decreased cAMP levels during the first hours following infection.
在KB细胞、MRC5细胞以及受低剂量仙台病毒感染的成人皮肤成纤维细胞中,感染后的最初数小时内细胞内环磷酸腺苷(cAMP)水平先上升后下降,随后在KB细胞和成人皮肤成纤维细胞中至少两天内一直低于基础水平。与先前描述的其他病毒或cAMP诱导剂相比,这种效应似乎是仙台病毒所特有的。文中讨论了cAMP变化的机制和作用。感染水泡性口炎病毒(VSV)的KB细胞在感染后的最初数小时内cAMP水平略有下降。