Schümichen C, Seifritz R, Hoffmann G
Nuklearmedizin. 1980 Aug;19(4):174-7.
The transfer of albumin into the extravascular space of bone and other tissues was evaluated in the non-adult rat and was found to be less rapid in bone than in the liver and kidneys but more rapid than in muscle. Protein binding of 99mTc increased continuously with time after injection of 99mTc-EHDP and -PPi. One hour after administration, about 20% of the plasma activity of 99mTc-EHDP and 90% of 99mTc-PPi was bound to proteins. Thus the possibility exists that the fixation of 99mTc through protein binding in the extravascular space of bone contributes significantly to the regular bone uptake of 99mTc-phosphates, in the event that relatively unstable compounds such as 99mTc-PPi are used.
在未成年大鼠中评估了白蛋白向骨骼及其他组织血管外间隙的转运情况，结果发现其在骨骼中的转运速度比在肝脏和肾脏中慢，但比在肌肉中快。注射99mTc-EHDP和-PPi后，99mTc的蛋白结合率随时间持续增加。给药1小时后，99mTc-EHDP血浆活性的约20%和99mTc-PPi的90%与蛋白质结合。因此，如果使用相对不稳定的化合物如99mTc-PPi，通过蛋白质结合在骨骼血管外间隙中固定99mTc很可能对99mTc-磷酸盐在骨骼中的正常摄取有显著贡献。
